Mechanism of action

After binding to the receptor, the steroid – receptor complex binds to chromatin and stimulates the formation of mRNA. The mRNA stimulates the synthesis of enzymes. The anti-inflammatory action is due to inhibition of prostaglandin and leukotriene synthesis. The actions of Prednisolone are

1. increased gluconeogenesis
2. increased lipolysis
3. increased liver stores of glycogen
4. CNS effects, euphoria
5. increased haemoglobin synthesis
6. Restrict capillary permeability and maintenance of cardiovascular function
7. cause normal skeletal muscular functions
8. anti-inflammatory action
9. suppression of immune response
10. stabilize lysosomal membranes
11. anti allergic action.