Mechanism of action
It exerts its action by stimulation of RNA polymerase A. It is a strong antioxidant and inhibits prostaglandin synthetase leading to decrease in prostaglandin synthesis. Silymarin changes the membrane phospholipid turnover in such a manner that certain toxins cannot enter the cell. It enhances the mitotic potential of Kupffer�s cells resulting in increased phagocytic activity. It also causes increased glutathione synthesis in liver, which is required for the detoxifying action of liver.