Mechanism of action
| It exerts its action by inhibiting aldehyde dehydrogenase enzyme. Disulfiram thus increases the concentration of acetaldehyde in body when ethanol is ingested by an individual pretreated with disulfiram. The symptoms and signs are flushing, pulsating headache, nausea, vomiting, thirst, marked uneasiness, vertigo, weakness, confusion, hypotension and circulatory collapse. |