Mechanism of action

Endocrine System: After binding to the receptor, the steroid receptor complex binds to chromatin and stimulates the formation of mRNA. The mRNA stimulates the synthesis of enzymes. The antiinflammatory action is due to inhibition of prostaglandin and leucotriene synthesis. The actions of glucocorticoids are:

1. increased gluconeogenesis.
2. increased lipolysis
3. increased liver stores of glycogen
4. CNS effects, euphoria
5. increased haemoglobin synthesis
6. restrict capillary permeability and maintenance of cardiovascular function
7. cause normal skeletal muscular function
8. antiinflammatory action
9. suppression of immune response
10. stabilize lysosomal membranes
11. antiallergic action.