Mechanism of action
| Cloxacillin is bactericidal and act by interfering with bacterial cell wall synthesis. Certain generalizations are useful for penicillins. After administration penicillins are widely distributed throughout body and therapeutic concentration is achieved in tissues and secretions such as pericardial fluid, pleural fluid, bile and joint fluid. Low concentration of these drugs is found in brain tissue, prostatic secretions and intraocular fluid. Penicillins are excreted fast by the kidney, hence have short plasma half-life. Blood levels of all penicillins can be raised by administration of Probenecid. Do not treat severe pneumonia, bacteraemia, meningitis, empyema, pericarditis or septic arthritis with oral penicillin during the acute stage. In case of history of allergy to Penicillin, they are contraindicated for use. |
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