Mechanism of action
| Intracellularly it is converted by cellular enzymes to the active metabolite, dideoxyadenosine 5-triphosphate. This metabolite inhibits the activity of HIV-1 reverse transcriptase both by competing with the natural substrate, and by its incorporation into viral DNA. The lack of a 3-hydroxyl group in the incorporated nucleoside analogue prevents DNA chain elongation and therefore, the viral DNA growth is terminated. |
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